The preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X‐ray crystallographic analysis, the methods of (...) molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug design. (shrink)

Recent business headlines, particularly those related to the collapsed energy-trading giant, Enron and its auditor, Arthur Andersen raise concerns about accountants' ethical reasoning. We propose, and provide evidence from 90 new auditors from Big-Five accounting firms, that a selection-socialization effect exists in the accounting profession that results in hiring accountants with disproportionately higher levels of the Sensing/thinking (ST) cognitive style. This finding is important and relevant because we also find that the ST cognitive style is associated with relatively low levels (...) of ethical reasoning, regardless of gender. This finding implies a need for emphasis on the ethical training of accountants. The results also suggest that accounting firms should consider recruiting accountants with cognitive styles associated with relatively higher levels of ethical reasoning. (shrink)

This is a book symposium on Steffen Borge’s The Philosophy of Football. It has contributions from William Morgan, Murray Smith and Brian Weatherson with replies from Borge.

This essay considers what it means to understand natural language and whether a computer running an artificial-intelligence program designed to understand natural language does in fact do so. It is argued that a certain kind of semantics is needed to understand natural language, that this kind of semantics is mere symbol manipulation (i.e., syntax), and that, hence, it is available to AI systems. Recent arguments by Searle and Dretske to the effect that computers cannot understand natural language are discussed, and (...) a prototype natural-language-understanding system is presented as an illustration. (shrink)

The model of clinical ethics consultation (CEC) defended in the ASBH Core Competencies report has gained significant traction among scholars and healthcare providers. On this model, the aim of CEC is to facilitate deliberative reflection and thereby resolve conflicts and clarify value uncertainty by invoking and pursuing a process of consensus building. It is central to the model that the facilitated consensus falls within a range of allowable options, defined by societal values: prevailing legal requirements, widely endorsed organizational policies, and (...) professional standards of practice and codes of conduct. Moreover, the model stipulates that ethics consultants must refrain from giving substantive recommendations regarding how parties to a moral disagreement in the clinic should evaluate their options. We argue that this model of CEC is incomplete, because it wrongly assumes that what counts as the proper set of allowable options among which the parties are to deliberate will itself always be clearly discernible. We illustrate this problem with a recent case on which one of us consulted—a neonate born with trisomy 18 (T18). We try to show that law, policy, and standards of practice reveal no clear answer to the question posed by the case: namely, whether forgoing gastrostomy tube feedings for a baby with T18 is allowable. We suggest there may be other kinds of cases in which it may simply be unsettled whether a given choice falls within the set of allowable options within which consensus is to be facilitated. What should an ethicist do when confronting such unsettled cases? We agree with the facilitation model that an ethicist should remain neutral among the allowable options, when it is clear what the allowable options are. But, in unsettled cases, the role of a consultant should be expanded to include a process of moral inquiry into what the allowable options should be. We end by raising the issue of whether this means an ethicist should share his or her own conclusions or views about the allowability of a given clinical option. (shrink)

This essay continues my investigation of `syntactic semantics': the theory that, pace Searle's Chinese-Room Argument, syntax does suffice for semantics (in particular, for the semantics needed for a computational cognitive theory of natural-language understanding). Here, I argue that syntactic semantics (which is internal and first-person) is what has been called a conceptual-role semantics: The meaning of any expression is the role that it plays in the complete system of expressions. Such a `narrow', conceptual-role semantics is the appropriate sort of semantics (...) to account (from an `internal', or first-person perspective) for how a cognitive agent understands language. Some have argued for the primacy of external, or `wide', semantics, while others have argued for a two-factor analysis. But, although two factors can be specified–-one internal and first-person, the other only specifiable in an external, third-person way–-only the internal, first-person one is needed for understanding how someone understands. A truth-conditional semantics can still be provided, but only from a third-person perspective. (shrink)

I advocate a theory of syntactic semantics as a way of understanding how computers can think (and how the Chinese-Room-Argument objection to the Turing Test can be overcome): (1) Semantics, considered as the study of relations between symbols and meanings, can be turned into syntax – a study of relations among symbols (including meanings) – and hence syntax (i.e., symbol manipulation) can suffice for the semantical enterprise (contra Searle). (2) Semantics, considered as the process of understanding one domain (by modeling (...) it) in terms of another, can be viewed recursively: The base case of semantic understanding –understanding a domain in terms of itself – is syntactic understanding. (3) An internal (or narrow ), first-person point of view makes an external (or wide ), third-person point of view otiose for purposes of understanding cognition. (shrink)

The evolutionist challenge to moral realism is the skeptical challenge that, if evolution is true, it would only be by chance, a “happy coincidence” as Sharon Street puts it, if human moral beliefs were true. The author formulates Street’s “happy coincidence” argument more precisely using a distinction between probabilistic sensitivity and insensitivity introduced by Elliott Sober. The author then considers whether it could be rational for us to believe that human moral judgments about particular cases are probabilistically sensitive to strongly (...) universal fundamental moral standards of cooperation and fair division. The author provides an explanation of why there would be a benign correlation between human moral judgments in particular cases and the requirements of strongly universal fundamental moral standards. The explanation of the benign correlation is based on group selection for groups of individuals with an egalitarian satisficing psychology and egalitarian norms, because of the ability of such groups to more efficiently solve gene-propagation collective action problems. (shrink)

Symbols in computer programs are not necessarily isomorphic in form or capability to neural processes. Representations in our models are stored descriptions of the world and human behavior, created by a human interpreter; representations in the brain are neither immutable forms nor encoded in some language. Although the term " symbol " can be usefully applied to describe words, smoke signals, neural maps, and graphic icons, a science of symbol processing requires distinguishing between the structural, developmental, and interactive nature of (...) different forms of representing. (shrink)

This paper describes the SNePS knowledge-representation and reasoning system. SNePS is an intensional, propositional, semantic-network processing system used for research in AI. We look at how predication is represented in such a system when it is used for cognitive modeling and natural-language understanding and generation. In particular, we discuss issues in the representation of fictional entities and the representation of propositions from fiction, using SNePS. We briefly survey four philosophical ontological theories of fiction and sketch an epistemological theory of fiction (...) using a story operator and rules for allowing propositions to migrate into and out of story spaces. (shrink)

A brief introduction to Meinong, his theory of objects, and modern interpretations of it. Sections include: The Theory of Objects, Castañeda's Theory of Guises, Parsons,'s Theory of Nonexistent Objects, Rapaport's Theory of Meinongian Objects, Routley's Theory of Items.

It seems impossible to foresee man's future. However, we do see clearly that the past determines our present in many realms : language, concept of the world, religion, science, law. Moreover, certain biological and physiological conditions appear to be so characteristic of the human species that we would not really be concerned with humanity if men managed to free themselves of these conditions.

This article argues that theism entails a species of pantheism on the grounds that there is simply no discernible difference between the God's knowledge of the world and the world that God knows. The case against this thesis begins with the traditional theory of distinctions. But since God is necessarily omniscient there is not even the possibility that these might be considered apart and thus distinguished in that way. But neither is it possible to do this by means of Leibnitz's (...) law, that is, by finding some feature possessed by the one but not the other. Three potential areas of difference are considered but rejected, first, that knowledge unlike the world is representational, and second, that knowledge unlike the world is phenomenal – there is something that it is like to have. Both of these features, though able to distinguish ordinary knowledge from its objects, cease to provide the difference we require when extended to the case of divine knowledge. A final area of potential difference lies in the transcendent nature of God over the world, especially with respect to time, finitude and possibility. But this, in the end, is found no more able to distinguish God's knowledge from its object than the previous two suggestions. (shrink)

It considers the epistemology of theology and features 42 chapters, divided into 4 sections on 'Theology Relative Epistemic Concepts' and 'General Epistemic Concepts as Related to Theology', and on studies of individual theologians from St Paul through to Hans Urs von Balthasar and of contemporary movements such as Liberation Theology and Feminism.

We argued in our joint article that the facilitated consensus model of clinical ethics consultation is incomplete because it does not address the problem of what we have called “unsettled cases.” Sabrina Derrington and April Dworetz, Mark Aulisio, and Al Jonsen have each usefully challenged our claims and conclusions. In this brief article we respond to some of their arguments.

A significant number of inmates with mental illness reside within the New York State Department of Corrections (NYSDOCS). New York State has taken the initiative to provide mentally ill inmates with necessary services through a collaboration of the New York State Department of Correctional Services and the New York State Office of Mental Health (NYSOMH). The collaboration results in a mental health delivery system that provides many essential services to mentally ill inmates. This paper focuses on the organization of mental (...) health services within NYSDOCS, best practices, past and current litigation, and staff responsibilities. As the population of mentally ill inmates continues to grow, implications for the Human Services professions of OMH and DOCS needs to continue to address and provide adequate mental health care and resources for this special population. (shrink)

The role of time in episodic memory and mental time travel is considered in light of findings on humans' temporal memory and anticipation. Time is not integral or uniform in memory for the past or anticipation of the future. The commonalities of episodic memory and anticipation require further study.

Own Yourself is "hands-on" course in ethics and morality. Its goal is to assist students to come to know who they genuinely are and who they want to become as they move into adulthood.

Rolston (1988) argues that in order to act ethically in the environment, moral agents must assume that their actions are potentially harmful, and then strive to prove otherwise before implementing that action. In order to determine whether or not an action in the environment is harmful requires the tools of applied epistemology in order to act in accord with Rolston’s ethical prescription. This link between ethics and epistemology demands a closer look at the relationship between confirmation theory, particularly notions of (...) plausibility, in the philosophy of science and environmental ethics. Upon taking this look, I conclude that, at least logically, we are no better off assuming that actions are maximally risky (Rolston) than when we assume minimal risk. “Our vulnerability to error is greatest not from the things that we include in the model, but from the prophecies we leave out entirely.” Francis Bretherton “What is the main epistemic problem concerning science? I take it that it is the explication of how we compare and evaluate theories, as a basis either for theory acceptance or for practical action.” Bas van Fraassen “We face two kinds of ethical difficulties. One is where we know what ought to be done but not how to get the company to do it. The other is where we do not know what is right. We do not know the facts, or how to weigh the facts, especially statistical ones. We do not know the probabilities for development of future technologies. We do not know how to attach values to facts, or how to trade this good off against that one.” Holmes Rolston. (shrink)